CD47 is a potent Don’t eat me signal that enables cancer cells to evade immune surveillance and killing by innate immune cells, such as macrophages.
By using bispecific antibodies with a high affinity targeting arm (against a tumor-associated antigen, or TAA) and an anti CD47 arm of an optimized low affinity, the Don’t eat me signal is blocked selectively on TAA-positive cells, leading to the effective engulfment and degradation of tumor cells by macrophages (left-hand part of the video).
Due to the absence of a tumor-specific targeting arm, a monovalent anti CD47 bsAb is unable to bind and block CD47, with tumor cells that can resist the attack of macrophages (right-hand part of the video).
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We are delighted to announce SIX exciting new articles featuring Nanolive’s 3D Cell Explorer. The articles come from users based in Taiwan, Poland, Spain, and Belgium, respectively. TP3, an antimicrobial peptide, inhibits infiltration and motility of glioblastoma...
We are delighted to announce three very exciting new PARISITOLOGY articles featuring Nanolive’s 3D Cell Explorer – ALL of which have been published this year by our prolific clients at the Justus Liebig University (Giessen, Germany) and their co-authors in Colombia...
We are happy to announce our next webinar with the topic "Accelerating oncology drug discovery with label-free imaging" on July 7th and 8th. In this webinar, Dr. Emma Gibbin, Communications Specialist at Nanolive will discuss the advantages of using label-free live...
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