Nobel Prize goes to James P. Allison and Tasuku Honjo for their discovery of cancer therapy by inhibition of negative immune regulation

Nanolive wants to congratulate the 2018 Nobel Prize in Physiology or Medicine who went to James P. Allison and Tasuku Honjo for their discovery of cancer therapy by inhibition of negative immune regulation.

By stimulating the inherent ability of our immune system to attack tumor cells this year’s Nobel Laureates have established an entirely new principle for cancer therapy. James P. Allison studied a known protein that functions as a brake on the immune system. He realized the potential of releasing the brake and thereby unleashing our immune cells to attack tumors. He then developed this concept into a brand new approach for treating patients.

In parallel, Tasuku Honjo discovered a protein on immune cells and, after careful exploration of its function, eventually revealed that it also operates as a brake, but with a different mechanism of action. Therapies based on his discovery proved to be strikingly effective in the fight against cancer. Allison and Honjo showed how different strategies for inhibiting the brakes on the immune system can be used in the treatment of cancer. The seminal discoveries by the two Laureates constitute a landmark in our fight against cancer!

Access to the full press release here (https://www.nobelprize.org/prizes/medicine/2018/press-release/)

Here a short video obtained with the 3D Cell Explorer showing a cancer cell being killed by a T-cell.

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