Costanzo-Garvey and colleagues studied the impact of direct neutrophil-prostate cancer interactions on prostate cancer growth. They unveiled a role of bone-resident neutrophils in inhibition of cancer growth. They also concluded that bone metastatic prostate cancer can progress via evasion of neutrophil-mediated killing. They suggest that an enhancement of neutrophil phototoxicity in bone could be a target on new bone metastatic prostate cancer therapies.
Nanolive’s 3D Cell Explorer was used in combination with Incucyte S3 live-cell Analysis for live cell imaging visualization of the apoptotic inducing role of neutrophils in prostate cancer (Figure 1).
Figure 1: Snapshot image of mouse neutrophils and C42B cells showing neutrophils surrounding a C42B cell with membrane blebbing (sign of apoptosis). Image obtained from .
 Costanzo-Garvey, D.L., Keeley, T., Case, A.J. et al. Neutrophils are mediators of metastatic prostate cancer progression in bone. Cancer Immunol Immunother (2020). https://doi.org/10.1007/s00262-020-02527-6