Revolutionary label-free 3D live cell imaging technology changes the future of stem cell research

Studying stem cells is amongst, if not THE biggest challenge in today’s biological research.

A better understanding of the inner mechanisms of stem cells could help fighting cancer, aging, degenerative diseases such as Alzheimer or organ failures such as heart diseases.

Advancing stem cell research with the 3D Cell Explorer

Scientists can discover more about the behavior of stem cells with Nanolive’s 3D live cell microscope – the 3D Cell Explorer. This microscope offers the best contrast, resolution and versatility that a label-free microscopic approach can offer today, coupled to unmatched time resolution. Last but not least, it’s 3D.

Please have a look at our stunning material: stem cells as never seen before!

 

Long Term Live Imaging of Mouse Embryonic Stem Cells for 34 hours!

High-frequency, long-term live imaging

One of the biggest challenges in cell biology is long-term imaging of fine cellular dynamics. In particular, the 3D Cell Explorer generates no phototoxicity as it injects in the sample ~100 times less energy (~0.2 nW/µm2) than light sheet microscopes (~1nW/µm2) that are the reference in the matter. With a resolution of 195nm (higher than standard confocal) it enables high resolution and high-frequency imaging even with sensitive material, such as stem cells*.

Unique dynamics of cellular organelles or highly dynamic and small cellular structures can now be clearly analyzed, such as mitochondria, lipid droplets, filopodia, dendrites, axons, nucleus and nucleoli etc.

With Nanolive’s live cell imaging tool, it is possible to perform endless live imaging at the maximal acquisition speed (1 image per 1.7 seconds). 

This certainly exceeds any live cell imaging capabilities of any other microscope and will revolutionize live cell imaging of stem cells.

(*plus, the next generation holotomographic technology used to make these movies is sold at a fraction of the cost of a standard confocal)

Learn more about the 3D Cell Explorer and its implications for long-term imaging of stem cells in our upcoming webinar. Follow this link for more information: https://nanolive.ch/stemcell-webinar/.

A big thank you to Aleksandra Mandic from the department of Biotechnology and Bioengineering at EPFL for preparing these amazing cell cultures for us!

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