Interactions & Reactions

"It is amazing to be able to directly visualize the cell in its natural media, without labeling and in 3D." Yasmine Abouleila and Ahmed Ali, RIKEN Research Institute

PHAGOCYTOSIS

Dictyostelium discoideum phagocytizing E.coli

 

 

Monitor phagocytosis and related cellular processes, in real-time

The 3D Cell Explorer allows for non-invasive, high resolution & 3D imaging of internalization processes

  • Observe & localize the presence of bacteria in the digestive vacuoles inside the amoebae
  • Monitor the whole pathogen cycle inside the host cell 
  • High temporal time-lapse resolution (3D/1.7s) allows for obtaining complete bacteria internalization process time-lapse

 

Technical Note

HOST-PATHOGEN INTERACTIONS

Human blood smear infected with Plasmodium falciparum

 

 

Monitor intra-cellular parasitic infections instantly & stain-free

Analyze the whole parasites life-cycle inside cells

  • Recognize the different phases of malaria parasite reproductive cycle
  • Monitor the infection progression inside cells in real-time
  • Study the morphological modifications caused by the parasite
  • Diagnose the disease in one second

 

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CELL-CELL INTERACTIONS

Mouse melanoma cancer cells incubated with Dictyostelium discoideum

 

 

Spy on how cells interact without getting noticed!

With the 3D Cell Explorer you can monitor cell-cell interactions in a totally stain-free fashion and in 3D

  • Identify different cell specimens based on their specific refractive index
  • Gather interaction information in 3D and 4D
  • Extract interactions kinetics & dynamics


 
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BACTERIA-CELL INTERACTIONS

HeLa cells infected with Chlamydia

 

 

Follow and study bacteria infections without stain!

With the 3D Cell Explorer you can monitor the whole life cycle of intra-cellular bacteria infection

  • Identify elementary bodies inside new infected cells
  • Follow the fusion of elementary bodies into inclusions and then into reticulate bodies until cell lysis
  • Measure size and volume of intra-cellular inclusions


 

ADHESION OF ERYTHROCYTES TO ENDOTHELIAL CELLS

Facile preparation of full-color emissive carbon dots and their applications in imaging of the adhesion of erythrocytes to endothelial cells

  • Characterize the adhesion of RBCs endothelial cells without the use of Fluorescence carbon dots

 

 

Publication