The main event in blood coagulation is fibrin network formation as a result of the polymerization of the soluble plasma protein fibrinogen . Alterations in this process lead to hemostatic and thrombotic disorders such as hemophilia  or thrombosis . Additionally, fibrin deposition in tumor cells plays an important role in the formation of the tumor stroma and in angiogenesis . Fibrin clots in cancer exist only within lesions, and their early identification represents a safe and effective method of diagnosis of invasive cancers . The footage shows fibrin network formation in MDA-MB-231 cells, a cell line from human breast adenocarcinoma. An image was obtained every 20 seconds during 15 minutes on Nanolive’s 3D Cell Explorer.
 Palta, S., Saroa, R., & Palta, A. (2014). Overview of the coagulation system. Indian journal of anaesthesia, 58(5), 515–523. https://doi.org/10.4103/0019-5049.144643
 Brummel-Ziedins, K. E., Branda, R. F., Butenas, S., & Mann, K. G. (2009). Discordant fibrin formation in hemophilia. Journal of thrombosis and haemostasis : JTH, 7(5), 825–832. https://doi.org/10.1111/j.1538-7836.2009.03306.x
 Korte W, Poon M, -C, Iorio A, Makris M: Thrombosis in Inherited Fibrinogen Disorders. Transfus Med Hemother 2017;44:70-76. doi: 10.1159/000452864
 Obonai, T., Fuchigami, H., Furuya, F. et al. Tumour imaging by the detection of fibrin clots in tumour stroma using an anti-fibrin Fab fragment. Sci Rep 6, 23613 (2016). https://doi.org/10.1038/srep23613
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Dr. Patrick Sandoz has been collaborating with Nanolive since 2013, first as a PhD student and then as a post-doc in Prof. van der Goot’s lab at EPFL (Lausanne, Switzerland). He played a very important role in testing Nanolive’s first microscope, the 3D Cell Explorer....
Human papillomavirus (HPV) is the most common viral sexually transmitted disease . Most sexually active individuals will become infected at some point in their lives. Of those infections, about 90% are asymptomatic and resolve spontaneously . Additionally, some...
We are delighted to announce that a new publication featuring Nanolive imaging has been published in BMC Molecular and Cell Biology. The study, a huge international collaboration spearheaded by Dr. Michael Cahill from the Charles Sturt University (NSW, Australia) and...
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