The main event in blood coagulation is fibrin network formation as a result of the polymerization of the soluble plasma protein fibrinogen . Alterations in this process lead to hemostatic and thrombotic disorders such as hemophilia  or thrombosis . Additionally, fibrin deposition in tumor cells plays an important role in the formation of the tumor stroma and in angiogenesis . Fibrin clots in cancer exist only within lesions, and their early identification represents a safe and effective method of diagnosis of invasive cancers . The footage shows fibrin network formation in MDA-MB-231 cells, a cell line from human breast adenocarcinoma. An image was obtained every 20 seconds during 15 minutes on Nanolive’s 3D Cell Explorer.
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