Scientific Publications

Peer Reviewed Articles, Conference Posters, Publications on Technology

2020

Bioenergetics Consequences of Mitochondrial Transplantation in Cardiomyocytes

Authors: Paria Ali Pour, M. Cristina Kenney and Arash Kheradvar

https://doi.org/10.1161/JAHA.119.014501

Published in: Journal of the American Heart Association

Specialized cytonemes induce self-organization of stem cells

Authors: Sergi JunyentClare L. GarcinJames L. A. SzczerkowskiTung-Jui TrieuJoshua Reeves, Shukry J. Habib

https://doi.org/10.1073/pnas.1920837117

Published in: National Academy of Sciences

Mesoporous silica nanoparticles functionalized with a dialkoxide diorganotin(IV) compound: In search of more selective systems against cancer cells

Authors: Diana Díaz-García, Lucia Sommerova, Andrea Martisova, Hana Skoupilova, Sanjiv Prashar, Tomas Vaculovic, Viktor Kanicky, Isabel del Hierro, Roman Hrstka, Santiago Gómez-Ruiz

https://doi.org/10.1016/j.micromeso.2020.110154

Published in: Microporous and Mesoporous Materials

Advancing methods for the analysis of glioblastoma cell motion using quantitative time lapse holographic imaging and cellular tomography

Authors: Ed Luther, Livia Mendes, Nina Filiczak, Aditi Jhaveri, Lara Milane, Vladimir Torchilin

https://doi.org/10.1117/12.2510236

Published in: Society of Photo-Optical Instrumentation Engineers

Mechanical Properties of cellulose fibers measured by Brillouin spectroscopy

Authors: Elsayad, K., Urstöger, G., Czibula, C. et al.

https://doi.org/10.1007/s10570-020-03075-z

Published in Cellulose 

Vaccination Against Amyloidogenic Aggregates in Pancreatic Islets Prevents Development of Type 2 Diabetes Mellitus

Authors: Elisa S. Roesti, Christina N. Boyle, Daniel T. Zeman, Marcos Sande-Melon, Federico Storni, Gustavo Cabral-Miranda, Alexander Knuth, Thomas A. Lutz, Monique Vogel and Martin F. Bachmann

https://doi.org/10.3390/vaccines8010116

Published in Vaccines

Stimuli-sensitive fatty acid-based microparticles for the treatment of lung cancer

Authors: Katarzyna Reczyńska, Patrycja Marchwica, Dipesh Khanal, Tomasz Borowik, Marek Langner, Elżbieta Pamuła, Wojciech Chrzanowski

https://doi.org/10.1016/j.msec.2020.110801

Published in Materials and Science Engineering: C

Neutrophils are mediators of metastatic prostate cancer progression in bone

Authors: Costanzo-Garvey, D.L., Keeley, T., Case, A.J. et al.

https://doi.org/10.1007/s00262-020-02527-6

Published in Cancer Immunology, Immunotherapy

Proinflammatory Effect of Carbon-Based Nanomaterials: In Vitro Study on Stimulation of Inflammasome NLRP3 via Destabilisation of Lysosomes

Authors: Svadlakova, T.; Hubatka, F.; Turanek Knotigova, P.; Kulich, P.; Masek, J.; Kotoucek, J.; Macak, J.; Motola, M.; Kalbac, M.; Kolackova, M.; Vankova, R.; Vicherkova, P.; Malkova, A.; Simeckova, P.; Volkov, Y.; Prina-Mello, A.; Kratochvilova, I.; Fiala, Z.; Raska, M.; Krejsek, J.; Turanek, J

https://doi.org/10.3390/nano10030418

Published in Nanomaterials

Besnoitia besnoiti bradyzoite stages induce suicidal- and rapid vital-NETosis

Authors: Ershun ZhouLiliana M. R. SilvaIván ConejerosZahady D. VelásquezManuela HirzUlrich GärtnerPhilippe JacquietAnja Taubert and Carlos Hermosilla

https://doi.org/10.1017/S0031182019001707

Published in Parasitology

Molecular heterogeneity in breast carcinoma cells with increased invasive capacities

Authors: Giulia Negro, Bertram Aschenbrenner, Simona Kranjc Brezar, Maja Cemazar, Andrej Coer, Gorana Gasljevic, Dragana Savic, Maxim Sorokin, Anton Buzdin, Maurizio Callari, Irma Kvitsaridze, Anahid Jewett, Mariela Vasileva-Slaveva, Ute Ganswindt, Prof. Ira Skvortsova, Sergej Skvortsov

https://doi.org/10.2478/raon-2020-0007

Published in The Journal of Association of Radiology and Oncology

Enhancement of the biological autoluminescence by mito-liposomal gold nanoparticle nanocarriers

Authors: Hadi Sardarabadi, Djamel Eddine Chafai, Fatemeh Gheybi, Pezhman Sasanpour, Hashem Rafii-Tabar, Michal Cifra

https://doi.org/10.1016/j.jphotobiol.2020.111812

Published in Journal of Photochemistry and Photobiology B: Biology

Optimized excystation protocol for ruminant Eimeria bovis- and Eimeria arloingi-sporulated oocysts and first 3D holotomographic microscopy analysis of differing sporozoite egress

Authors: Sara López-Osorio, Liliana M.R.Silva, Jenny J.Chaparro-Gutierréz, Zahady D.Velazquez, Anja Taubert, Carlos Hermosilla

https://doi.org/10.1016/j.parint.2020.102068

Published in Parasitology International

PGRMC1 phosphorylation affects cell shape, motility, glycolysis, mitochondrial form and function, and tumor growth

Authors: Bashar M. Thejer, Partho P. Adhikary, Amandeep Kaur et al.

https://doi.org/10.21203/rs.2.22342/v1

Published in BMC Molecular and Cell Biology

Impaired Glycolysis Promotes Alcohol Exposure-Induced Apoptosis in HEI-OC1 Cells via Inhibition of EGFR Signaling

Authors: Hyunsook Kang, Seong Jun Choi, Kye Hoon Park, Chi-Kyou Lee, and Jong-Seok Moon

https://doi.org/DOI: 10.3390/ijms21020476

Published in International Journal of Molecular Sciences

A Gain-Of-Function RAC2 Mutation Is Associated With Bone-Marrow Hypoplasia And An Autosomal Dominant Form Of Severe Combined Immunodeficiency

Authors: Chantal Lagresle-PeyrouAurélien OlichonHanem SadekPhilippe RocheClaudine TardyCindy Da SilvaAlexandrine GarrigueAlain FischerDespina MoshousYves ColletteCapucine PicardJean Laurent CasanovaIsabelle AndréMarina Cavazzana

https://doi.org/10.3324/haematol.2019.230250

Published in Haematologica Journal of The Ferrata Storti Foundation

Caspase-8 deficiency induces a switch from TLR3-induced apoptosis to lysosomal cell death in neuroblastoma cell lines

Authors: Marie-Anaïs Locquet, Gabriel IchimAurelie DutourSerge Lebeque, Marie Castets, Kathrin Weber

https://doi.org/10.1101/2020.01.13.904987

Published in BioRxiv

A potential hydrodynamic mechanism for cytoplasmic transfer between mammalian cells: Cell-projection pumping

Authors: Hans Zoellner, Navid Paknejad, James Cornwell, Belal Chami, Yevgeniy Romin, Vitaly Boyko, Sho Fujisawa, Elizabeth Kelly, Garry W. LynchGlynn RogersKatia ManovaMalcolm A.S. Moore

https://doi.org/10.1101/531798

Published in BioRxiv

2019

Image-based analysis of living mammalian cells using label-free 3D refractive index maps reveals new organelle dynamics and dry mass flux

Authors: Patrick A. Sandoz, Christopher Tremblay, F. Gisou van der Goot, Mathieu Frechin

PLoS Biol. 2019 Dec; 17(12): e3000553

https://doi.org/10.1371/journal.pbio.3000553

Published in PLOS Biology

E-Cigarette Use Increases Susceptibility to Bacterial Infection by Impairment of Human Neutrophil Chemotaxis, Phagocytosis and NET Formation

Authors: Ross Corriden, Alexander Moshensky, Christine M Bojanowski, Angela Meier, Jason Chien, Ryan K Nelson, Laura E. Crotty Alexander

https://doi.org/10.1152/ajpcell.00045.2019

Published in American Journal of Physiology

S-Nitrosothiol Plasma-Modified Surfaces for the Prevention of Bacterial Biofilm Formation

Authors: Zahra Sadrearhami, Rashin Namivandi-Zangeneh, Emily Price, Marta Krasowska, Sameer A Al-Bataineh, Jason Whittle, Edgar H. H. Wong, Anton Blencowe, Cyrille Boyer

ACS Biomater. Sci. Eng. 2019, 5, 11, 5881-5887

https://doi.org/10.1021/acsbiomaterials.9b01063

Published in ACS Publications

Toxoplasma gondii-induced host cellular cell cycle dysregulation is linked to chromosome missegregation and cytokinesis failure in primary endothelial host cells

Authors: Velásquez ZD, Conejeros , Larrazabal C , Kerner K, Hermosilla C, Taubert A.

https://doi.org/10.1038/s41598-019-48961-0

Published in Scientific Reports

Beyond the suprachiasmatic nucleus: circadian rhythmicity shapes astrocyte morphology and neuronal function in hippocampal area CA1

Authors: John P. McCauley, Maurice A. Petroccione, Lianna Y. D’Brant, Gabrielle C. Todd, Nurat Affinnih, Justin J. Wisnoski, Shergil Zahid, Swasti Shree, Alioscka A. Sousa, Rosanna Migliore, Alexey Brazhe, Richard D. Leapman, Alexander Khmaladze, Alexey Semyanov, Michele Migliore and Annalisa Scimemi

https://doi.org/10.1101/666073

Published in bioRxiv

Autophagosome accumulation-mediated ATP energy deprivation induced by penfluridol triggers nonapoptotic cell death of lung cancer via activating unfolded protein response

Authors: Wen-Yueh Hung, Jer-Hwa Chang, Yu Cheng, Guo-Zhou Cheng, Hsiang-Ching Huang, Michael Hsiao, Chi-Li Chung, Wei-Jiunn Lee and Ming-Hsien Chien

https://doi.org/10.1088/1742-6596/1236/1/012015

Published in Cell Death & Disease

Quantification of changes in cellular morphology during cell necrosis obtained from 3D refractive index distributions

Authors: D A Gorbenko, A V Belashov, T N Belyaeva, E S Kornilova, I V Semenova and O S Vasyutinskii

https://doi.org/10.1088/1742-6596/1236/1/012015

Published in Journal of Physics

Pleiotropic Effects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond

Authors: T. B. Steinbichler, D. Savic, D. Dejaco, A. Romani, B. Kofler, I. I. Skvortsova, H. Riechelmann, J. Dudas

https://doi.org/10.1007/s12307-019-00228-y

Published in Cancer Microenvironment

Endocytosis-mediated mitochondrial transplantation: Transferring normal human astrocytic mitochondria into glioma cells rescues aerobic respiration and enhances radiosensitivity

Authors: Chao Sun, Xiongxiong Liu, Bing Wang, Zhenhua Wang, Yang Liu, Cuixia Di, Jing Si, Hongyan Li, Qingfeng Wu, Dan Xu, Ji Li, Gang Li, Yupei Wang, Fang Wang and Hong Zhang

https://dx.doi.org/10.7150%2Fthno.33100

Published in Theranostics

BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative Phosphorylation in Human Lung Cancer Cells

Authors: Meng-Hsuan Cheng, Hung-Ling Huang, Yen-You Lin, Kuan-HaoTsui, Pei-Chin Chen, Shu-Yu Cheng, Inn-Wen Chong, Ping-JyunSung, Ming-Hong Tai, Zhi-Hong Wen, Nan-Fu Chen, and Hsiao-Mei Kuo

https://doi.org/10.1155/2019/6342104

Published in Oxidative Medicine and Cellular Longevity journal

Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction

Authors: Gabriela Pinget, Jian Tan, Bartlomiej Janac, Nadeem O. Kaakoush, Alexandra Sophie Angelatos, John O’Sullivan6, Yen Chin Koay, Frederic Sierro, Joel Davis, Shiva Kamini Divakarla, Dipesh Khanal, Robert J. Moore, Dragana Stanley, Wojciech Chrzanowski and Laurence Macia

https://doi.org/10.3389/fnut.2019.00057

Published in frontiers in Nutrition

Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells

Authors: Liliana M. R. Silva, Dieter Lütjohann, Penny Hamid, Zahady D. Velasquez, Katharina Kerner, Camilo Larrazabal, Klaus Failing, Carlos Hermosilla & Anja Taubert

https://doi.org/10.1038/s41598-019-43153-2

Published in Scientific Reports

Methamphetamine-induced apoptosis in glial cells examined under markerfree imaging modalities

Authors: Lianna Y. D’Brant, Habben Desta, Ting Chean Khoo, Anna V. Sharikova, Supriya D. Mahajan, Alexander Khmaladze

https://doi.org/10.1117/1.JBO.24.4.046503

Published in Journal of Biomedical Optics

Synthesis of fluorescent molybdenum nanoclusters at ambient temperature and their application in biological imaging

Authors: Amit Kumar Sharma, Sunil Pandey, Nallin Sharma, Hui-Fen Wu

https://doi.org/10.1016/j.msec.2019.01.029

Published in Material Science and Engineering: C

Diagnosing water treatment critical control points for cyanobacterial removal: Exploring benefits of combined microscopy, next-generation sequencing, and cell integrity methods

Authors: Arash Zamyadi, Caitlin Romanis, Toby Mills, Brett Neilan, Florence Choo, Lucila A., Coral, Deb Gale, Gayle Newcombe, Nick Crosbie, Richard Stuetz, Rita K. Henderson

https://doi.org/10.1016/j.watres.2019.01.002

Published in Water Research

Antibiofilm Nitric Oxide Releasing Polydopamine Coatings

Authors: Zahra Sadrearhami, Farah Nabilah Shafiee, Kitty Ka Kit Ho, Naresh Kumar, Marta Krasowska, Anton Blencowe, Edgar H. H. Wong, and Cyrille Boyer

ACS Appl. Mater. Interfaces 2019, 11, 7, 7320-7329

https://doi.org/10.1021/acsami.8b16853

Published in ACS Publications

Degradation of Mitochondria and Oxidative Stress as the Main Mechanism of Toxicity of Pristine Graphene on U87 Glioblastoma Cells and Tumors and HS-5 Cells

Authors: Sławomir Jaworski, Barbara Strojny, Ewa Sawosz, Mateusz Wierzbicki, Marta Grodzik, Marta Kutwin, Karolina Daniluk and André Chwalibog 

Int. J. Mol. Sci. 201920(3), 650

https://doi.org/10.3390/ijms20030650

Published in Publishing International Journal of Molecular Sciences

2018

Morphological changes in the ovarian carcinoma cells of Wistar rats induced by chemotherapy with cisplatin and dioxadet

Authors: A. A. Zhikhoreva, A. V. Belashov, V. G. Bespalov, A. L. Semenov, I. V. Semenova, G. V. Tochilnikov, N. T. Zhilinskaya, and O. S. Vasyutinskii

Vol. 9, Issue 11, pp. 5817-5827, (2018)

https://doi.org/10.1364/BOE.9.005817

Published in OSA Publishing

Label free 3D analysis of organelles in living cells by refractive index shows pre-mitotic organelle spinning in mammalian stem cells

Authors: Patrick A Sandoz, Christopher Tremblay, Sebastien Equis, Sorin Pop, Lisa Pollaro, Yann Cotte, Gisou F van der Goot, Mathieu Frechin

https://doi.org/10.1101/407239

Pre-published in bioRxiv

Label-Free Digital Holo-tomographic Microscopy Reveals Virus-Induced Cytopathic Effects in Live Cells

Authors: Artur Yakimovich, Robert Witte, Vardan Andriasyan, Fanny Georgi, Urs F Greber

https://doi.org/10.1128/mSphereDirect.00599-18

Published in American Society for Microbiology

Parvalbumin alters mitochondrial dynamics and affects cell morphology

Authors: Lucia Lichvarova, Thomas Henzi, Dzhamilja Safiulina, Allen Kaasik, Beat Schwaller

Volume 75, Issue 24, pp 4643–4666

https://doi.org/10.1007/s00018-018-2921-x

Published in: Springer Link

Superresolved and reference-free microparticle traction force microscopy (MP-TFM) reveals the complexity of the mechanical interaction in phagocytosis

Authors: Daan VorselenYifan WangMatthew J FooterWei CaiJulie A Theriot

https://doi.org/10.1101/431221

Pre-published in bioRxiv

Live-stream characterization of cadmium-induced cell death using visible CdTe-QDs

Authors: Samira Filali, Alain Geloën, Vladimir Lysenko, Fabrice Pirot & Pierre Miossec

https://doi.org/10.1038/s41598-018-31077-2

Published in: Scientific Reports 

Nanoparticles Based on Poly(trimethylene carbonate) Triblock Copolymers with Post-Crystallization Ability and Their Degradation in vitro

Authors: Lucie Reinišová, Filip Novotný, Martin Pumera, Katarína Kološtová, Soňa Hermanová

Volume 26, Issue 11, pp 1026–1034

https://doi.org/10.1007/s13233-019-7007-6

Published in: Springer Link 

Enhancing the antimicrobial and antibiofilm effectiveness of silver nanoparticles prepared by green synthesis

Authors: Susan Oliver,  Harsha Wagh, Yuanli Liang, Shuang Yang  and  Cyrille Boyer*

https://doi.org/10.1039/C8TB00907D

Published in: Journal of Materials Chemistry B

Nitric Oxide-Loaded Antimicrobial Polymer for the Synergistic Eradication of Bacterial Biofilm

Authors: Rashin Namivandi-Zangeneh, Zahra Sadrearhami, Ali Bagheri, Maeva Sauvage-Nguyen, Kitty Ka Kit Ho,Naresh Kumar, Edgar H. H. Wong, and Cyrille Boyer

ACS Macro Lett. 2018, 7, 5, 592-597

https://doi.org/10.1021/acsmacrolett.8b00190

Published in: ASC Macro Letter

The Effects of Polymer Topology and Chain Length on the Antimicrobial Activity and Hemocompatibility of Amphiphilic Ternary Copolymers

Authors: Rashin Namivandi Zangeneh, Rebecca J. Kwan, Thuy-Khanh Nguyen, Jonathan Yeow, Frances L. Byrne, Stefan H. Oehlers, Edgar Wong and Cyrille Boyer

https://doi.org/10.1039/C7PY01069A

Published in: Polymer Chemistry Journal

2017

Facile preparation of full-color emissive carbon dots and their applications in imaging of the adhesion of erythrocytes to endothelial cells

Authors: Zhiqiang Lai, Xiaojuan Yang ,Aiqun Li, Youyi Qiu, Jiye Cai  and  PeiHui Yang 

https://doi.org/10.1039/C7TB00567A

Published in: Journal of Materials Chemistry B

The selexipag active metabolite ACT-333679 displays strong anti-contractile and anti- remodeling effects, but low β-arrestin recruitment and desensitization potential

Authors: Gatfield J., Menyhart K., Wanner D., Gnerre C., Monnier L., Morrison K., Hess P., Iglarz M., Clozel M. and Nayler O.

https://doi.org/10.1124/jpet.116.239665

Published in: The Journal of Pharmacology and Experimental Therapeutics

2016

Live Single-cell Mass Spectrometry with Spatial Quantitation by Three-Dimensional Holographic and Tomographic Laser Microscopy

Authors: Ali A, Abouleila Y, Amer S, Furushima R, Emara S, Equis S, Cotte Y, Masujima T

2016 Volume 32 Issue 2 Pages 125-127

https://doi.org/10.2116/analsci.32.125

Published in: Analytical Sciences as Rapid Communication

Tomographic Holographic Microscopy for Nano-Scale Dose Calculation and Assessing Gold Nanoparticle Uptake in Live Cells

ASTRO 2016

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Grassberger C, Dinkelborg P, McNamara A, Schuemann J, McMahon S*, Willers H, Paganetti H, Wang M

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Marker-free phase nanoscopy

Nature Photonics, 2013

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„We introduce a microscopic method that determines quantitative optical properties beyond the optical diffraction limit and allows direct imaging of unstained living biological specimens. In established holographic microscopy, complex fields are measured using interferometric detection, allowing diffraction-limited phase measurements. Here, we show that non-invasive optical nanoscopy can achieve a lateral resolution of 90 nm by using a quasi-2π-holographic detection scheme and complex deconvolution. We record holograms from different illumination directions on the sample plane and observe subwavelength tomographic variations of the specimen. Nanoscale apertures serve to calibrate the tomographic reconstruction and to characterize the imaging system by means of the coherent transfer function. This gives rise to realistic inverse filtering and guarantees true complex field reconstruction. The observations are shown for nanoscopic porous cell frustule (diatoms), for the direct study of bacteria (Escherichia coli), and for a time-lapse approach to explore the dynamics of living dendritic spines (neurones).

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Nanomicroscopy for Live Cell tomography

The Handbook of Nanomedicine, Third Edition, 2017

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„Nanolive‘s Cell Explorer‘s technology enables determination of how light propagets through the cell [… ] Applications of this technology, which is commercially available, will enable discoveries on living cells and study of diseases as well as effects of drugs at cell level. It will be useful for recording celular uptake as well as localization of metal nanoparticles and assessments of cell exposure to nanoparticles.

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Characterising live cell behaviour: Traditional label-free and quantitative phase imaging approaches

The International Journal of Biochemistry & Cell Biology, 2017

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“2.2. Quantitative phase imaging:  Commercially-available QPI systems can be broadly classified according to the phase retrieval method utilised: (i) off-axis digital holography (PhiAB, Nanolive, Lyncee Tec, Tescan,1 Ovizio); (ii) wavefront sensing (Phasics); (iii) spatial light interference (Phi Optics); (iv) ptychography (Phasefocus).”

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