Host-pathogen interactions

Long term non-invasive live cell imaging of host-pathogen interactions at a cellular level

The non-invasiveness of Nanolive’s label- and phototoxicity-free technology enables the study of pathogens and their role in disease progression and can help the development of vaccines and treatments.

Virology: Virus-induced cytopathic effects

This video reveals virus-induced cytopathic effects in living cells. Virus infections have a physical signature (Refractive Index) which can be detected with the 3D Cell Explorer.

The Greber Group of the University of Zurich published a paper describing how Nanolive imaging reveals distinct patterns of virus infections in live cells with minimal perturbation.

Read the author’s exclusive interview on how different viruses infect living cells and discover more videos here.

Learn more in our virology section.

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Bacterial infections: Listeria

 

In this video we can observe mouse macrophages that have been infected with Listeria monocytogenes. It shows cell division and listeria propagation to daughter cells.

Read our detailed blogpost here.

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Protozoa: P. falciparum’s intra-erythrocytic cycle, an important immune escape strategy in Malaria

Internalization of the parasite in the host red blood cells entails not just avoiding macrophages detection, but also degrading huge amounts of haemoglobin.

This loss of haemoglobin is visible under the 3D Cell Explorer. During its life cycle, the parasite’s shape does not remain constant. Indeed, its life cycle goes through different stages as shown in this video.

Read our detailed blogpost here.

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Protozoa: P. falciparum’s intra-erythrocytic cycle, an important immune escape strategy in Malaria

Internalization of the parasite in the host red blood cells entails not just avoiding macrophages detection, but also degrading huge amounts of haemoglobin.

This loss of haemoglobin is visible under the 3D Cell Explorer. During its life cycle, the parasite’s shape does not remain constant. Indeed, its life cycle goes through different stages as shown in this video.

Read our detailed blogpost here.

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Apicomplexa: Toxoplasma Gondii

 

In this footage, we can distinguish T. gondii’s apical ring-shaped complex in tachyzoites from a Toxoplasma gondii infection in mouse fibroblasts (MEF1 T2). This structure plays a key role in host cell invasion processes.
The 3D render obtained solely from the sample’s refractive index, an inherent characteristic from it (thus, from a non-stained sample) is compared to a static image obtained from confocal laser-scanning microscopy.

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Video library

E.coli being engulfed through phagocytosis

Read our blogpost here.

 

E.coli being engulfed through phagocytosis

Read our blogpost here.

 

 

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