Toxicology studies

PHARMACODYNAMICS

human pulmonary arterial smooth muscle cells exposed to selexipag active metabolite ACT-333679

Measure cellular morphological changes induced by drug treatment

The 3D Cell Explorer allows for quantitative imaging of living cells after drug exposure

  • Cell measurements related to shape changes
  • Cell contraction/relaxation in 4D at every second
  • Monitor cell organelles and their modification induced by drugs
  • Extract quantitative data (cell size, nuclear volume, mitochondria disruption, …)

ABSOLUTE QUANTITATION OF LIVE SINGLE CELLS

Absolute quantitation of a single cancer cell by live single cell mass spectrometry coupled with 3D holography and tomography

 

Absolute quantitation of single cells or organelles by live single cell mass spectrometry coupled with 3D holo-tomography.

Precise volume analysis of intra-cellular components

  • Determine the exact concentration of drugs at a single cell or sub-cellular level by combination with mass spectrometry
  • Measure the contents of a single cell or organelle (picoliters or less)

CELL FEATURE PROFILING

HeLa cells treated with Vacuolin-1

Morphological profiling of cell organelles on live cells

With the 3D Cell Explorer you can extract quantitative data from 3D microscopy images or 4D time-lapses of live cells to identify
biologically relevant similarities and differences among samples based on these profiles
  • Identify biologically relevant similarities and differences among samples
  • identifies and measure morphological features (volume, shape, etc.)
  • Detect your cell phenotype in one second and in 3D