Live cell imaging

Living cell imaging

Nanolive is a start-up based in Lausanne, Switzerland. Created in 2013, the company is currently composed by 15 employees. It develops the 3D Cell Explorer, a high-tech microscope which brings a great innovation to living cell imaging: the 3D Cell Explorer. Through the introduction of this last generation of 3D microscopy, Nanolive shows that it is an ambitious company, and takes the challenge of developing the living cell study, in order to develop new drugs and medical treatments.

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3D Cell Explorer for imaging live cells more precisely than ever

The 3D Cell Explorer is a revolutionary microscope that allows cell’s deep observation. The image resolution acquired with this appliance is of 200 nm, whereas the theoretical limit is only 310 nm. With such precision, it is now possible to perform living cell imaging in real time, without damaging the cell. Based on scanning and holography technologies, 3D Cell Explorer allows giving contrast to the cell to be studied, without having to resort to the use of chemicals.

The living cell imaging and the “tomographic” information

The microscope developed by Nanolive uses holographic technology, which consists in measuring the refractive index of the cell. This measure is combined with a rotating scanning system to illuminate the cell with a soft light beam, which does not damage the sample. The tomographic information is what has emerged with the use of this new generation microscope. This non-invasive exploration with 3D Cell Explorer is done without chemical marking, complex manipulation or interference. To analyze the heart of the living cell, STEVE, an easy-to-use software, is created to help observing cell behavior from a computer screen. This software can be downloaded for free from Nanolive’s website. In addition, this software can reconstruct a 3D image of the cell studied, to produce unique living cell imaging.

Nanolive’s technology compared to fluorescence microscopy

With fluorescence microscopy, a sample preparation prior to study is essential. This can last from one hour to three hours and can cost a relevant amount of money due to the use of reagents. With the 3D Cell Explorer, no sample preparation is required. This allows for infinite live cell imaging and saves times and money, without altering the cell. Moreover, Nanolive’s technology provides very precise and clear 3D living cell imaging. With the tomography technology, it is possible to obtain an image per second, and to observe the behavior of living cells in real time. The 3D Cell Explorer is therefore a revolution in living cell imaging, and will benefit pharmaceutical, biotechnology, laboratories and universities.

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