Holographic microscope

The holographic microscope : a new microscopy approach

Nanolive, a startup based in Lausanne, Switzerland, has developed a revolutionary microscope which allows the exploration of a living cell in 3D without damaging it. This is a new optical microscopy approach, combining holography technology and rotational scanning.

The goal is to push the limits of traditional optical microscopy, and to allow 3D tomographic exploration of living cells. Nanolive has therefore introduced the 3D Cell Explorer, the new generation holographic microscope.

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The technology behind the holographic microscope

If most scientists still boast of a finer resolution with an electron microscope, approach with these microscopes does not allow living cell examination. For a long time, looking inside a living cell with optical microscopes would be impossible, because of their physical limitations. With Nanolive researchers, exploring the physical structure of a living cell is now possible with the 3D Cell Explorer, an outstanding holographic microscope.

This Nanolive technology may offer an undisturbed and so far unnoticed glimpse of a living cell. More importantly, it is not necessary to conduct prior process or long preparation of the cell. In fact, the 3D Cell Explorer monitoring operation is completely non-invasive to the cell. In addition, the 3D Cell Explorer allows observing parts of a cell up to 70 nm.

With the use of a conventional optical microscope, preparation process takes more than four hours and results in the death of the cell. With this holographic microscope, the same result can be achieved only in five minutes, allowing the observation of unstained living cells. This microscope is used to measure the various cellular processes in real time. It also allows extensive cell analysis, such as estimates of the cell volume.

A new generation microscope

The 3D Cell Explorer displays the cell in a completely new way, with a full representation of its morphology. This Nanolive technology is a major step in microscopy history, and can change all the rules in various fields such as medicine, education, biology, pharmacy, cosmetics and industry. Indeed, in the field of medicine, this holographic microscope helps to shed light on a disease. Any disease often comes down to the dysfunction of a cell. To understand the details of an illness, it is necessary to know the morphology of a cell and its possible dysfunction. 3D Cell Explorer makes it easy to indulge in this formerly complex operation.

This new generation microscope is based on a technology using refraction system, allowing it to function as a medical imaging apparatus in hospitals. The 3D Cell Explorer takes a complete tomographic image of the refractive index within the living cell. For the first time, therefore, it is possible to watch in real time within a cell and discovering its interior, as its core and its various organs. It is also possible to see and accurately measure the impact of stimuli and drugs on cells, allowing the pharmacological industry to access new areas of research on more efficient pharmaceutical products. In short, the 3D Cell Explorer is a holographic microscope that challenges conventional procedures for cell observation.

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