Characterizing cell-material interactions
High-resolution 3D characterization of cell-material interactions for the development of nanomaterials for regenerative medicine Request a demo or quoteStudying the effect of gold nanoparticles on cell morphology
In this video, we observe the morphological changes glioblastoma cancer cells undergo after the administration of gold nanorods. Images were captured every 5 mins for 4 h using the 3×3 gridscan mode on the 3D Cell Explorer 96focus (a field of view of 236×236 μm). Cell health is clearly negatively impacted by the presence of the AuNPs; they develop a substantial number of apoptotic bodies, and lose focal adhesion contact points, before shrinking in size. The files used to create this video were kindly provided by Dr. Joanna Depciuch, who runs a lab in the Department of Functional Nanomaterials, based at the Institute of Nuclear Physics Polish Academy of Sciences (Krakow, Poland).
Read our blogpost here.
Imaging the responses of living cells to different surface roughness
Human osteoblast-like cells (MG-63) were imaged for 2 hours; 1 image every 10 s. The video shows how cells interact with smooth and porous polycaprolactone (PCL) fibers. The cells were imaged using the 3D Cell Explorer. The files used to create this video were kindly provided by Prof. Urszula Stachewicz at the AGH University of Science and Technology (Kraków, Poland).
Read our dedicated blogpost here.
Tracking the internalization of nanocarriers in 3D
In this video, we observe the localization of nanocarriers in the mitochondria of U2OS cells. The files used to create this video were kindly provided by Dr. Michal Cifra from the Institute of Photonics and Electronics Academy of Sciences (Czech Republic).
Read our blogpost here.
Capturing mesenchymal stem cell interactions with 3D hydrogels
For this video, mesenchymal stem cells were grown in 3D PEG hydrogels of varying degrees of stiffness, kindly provided by Dr. Sonja Giger and Prof. Matthias Lutolf from EPFL, Switzerland. One image was taken every 30 secs. A post-processing colour scale was applied to data in the z-axis, to add spatial information to our images. Blue indicates where the cell is closer to the surface of the gel, while pink indicates where it is further away.
Find out more on our dedicated 3D Cell Culture page here.
Scientific publications
Nanolive label-free live cell imaging has already shed light on many important topics in the field of cell-material interactions research. To get inspired and learn how your research can benefit from our technology, we invite you to check out these scientific articles published by our clients.
Video library
Imaging the morphological changes cells undergo following exposure to toxic levels of drug delivery carriers
Read blogpost here
Bispecific antibodies being used as a T-cell targeting system to wipe out cancer cells
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Superparamagnetic iron oxide nanoparticles (SPIONs) under Nanolive 3D Cell Explorer-fluo
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Nanolive imaging and analysis platforms
Swiss high-precision imaging and analysis platforms that look instantly inside label-free living cells in 3D
3D CELL EXPLORER 96focus
Automated label-free live cell imaging and analysis solution: a unique walk-away solution for long-term live cell imaging of single cells and cell populations
3D CELL EXPLORER-fluo
Multimodal Complete Solution: combine high quality non-invasive 4D live cell imaging with fluorescence
3D CELL EXPLORER
Budget-friendly, easy-to-use, compact solution for high quality non-invasive 4D live cell imaging