Microbial infections

In this page you will have the possibility to explore MICROBIAL INFECTIONS as we see it: in 3D and stain free! Enjoy and stay tuned: the list of results grows every week…

 The 3D Cell Explorer allow for:

  • Malaria parasite detection
  • Life Cycle of the Malaria Parasite studies
  • Label-free Chlamydia infection detection

Despite the extensive use of antibiotic and vaccination programmes, infectious diseases (induced by  bacteria, viruses, fungi, or parasites) continue to be a leading cause of morbidity and mortality worldwide. One of the principal tools in the diagnosis of infectious disease is microscopy. Virtually all of the isolation techniques require a microscopic examination at some point for definitive identification of the infectious agent. The usual routine consists of staining the specimen (with specific chemical markers) in order to give the parasites a distinctive aspect. However, there are some drawbacks: the staining and interpretation processes are labour intensive, time consuming, and require considerable expertise and trained workers. These limitations could be solved thanks to the 3D Cell Explorer. Using only untreated samples, (not fixed and not stained) Nanolive’s technology is able to identify in a few seconds the cells that have been infected by parasites, allowing their discrimination from uninfected cells.

Malaria detection in RBCs

A sample of blood infected with Plasmodium malariae was fixed and imaged using the 3D Cell Explorer.  For a more detailed comparison of infected cells with healthy red blood cells check out our blog post.

HeLa cells infected by Chlamydia parasites

Living HeLa cells infected by Chlamydia trachomatis were imaged with the 3D Cell Explorer. The parasite inclusion bodies are displayed in green inside the cell cytoplasm.

Learn more about the 3D Cell Explorer

Read more about the 3D Cell Explorer here and learn how to use it in 1 minute with this video

 

Discover all the secrets of the 3D Cell Explorer on our Introductory webinar

Learn how to digitally stain your cells with our software STEVE, in 1 minute

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Related topics

Want to see more about cell-bacteria interactions?  Check out our designated application page

For more information, check out our blog post on Malaria!

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