Interactions & Reactions

PHAGOCYTOSIS

Dictyostelium discoideum phagocytizing E.coli

 

 

Monitor phagocytosis and related cellular processes, in real-time

The 3D Cell Explorer allows for non-invasive, high resolution & 3D imaging of internalization processes

  • Observe & localize the presence of bacteria in the digestive vacuoles inside the amoebae
  • Monitor the whole pathogen cycle inside the host cell 
  • High temporal time-lapse resolution (3D/1.7s) allows for obtaining complete bacteria internalization process time-lapse

 

HOST-PATHOGEN INTERACTIONS

Human blood smear infected with Plasmodium falciparum

 

 

Monitor intra-cellular parasitic infections instantly & stain-free

Analyze the whole parasites life-cycle inside cells

  • Recognize the different phases of malaria parasite reproductive cycle
  • Monitor the infection progression inside cells in real-time
  • Study the morphological modifications caused by the parasite
  • Diagnose the disease in one second

 

CELL-CELL INTERACTIONS

Mouse melanoma cancer cells incubated with Dictyostelium discoideum

 

 

Spy on how cells interact without getting noticed!

With the 3D Cell Explorer you can monitor cell-cell interactions in a totally stain-free fashion and in 3D

  • Identify different cell specimens based on their specific refractive index
  • Gather interaction information in 3D and 4D
  • Extract interactions kinetics & dynamics


 

BACTERIA-CELL INTERACTIONS

HeLa cells infected with Chlamydia

 

 

Follow and study bacteria infections without stain!

With the 3D Cell Explorer you can monitor the whole life cycle of intra-cellular bacteria infection

  • Identify elementary bodies inside new infected cells
  • Follow the fusion of elementary bodies into inclusions and then into reticulate bodies until cell lysis
  • Measure size and volume of intra-cellular inclusions