Cancer detection

On this page you will have the chance to detect CANCER in tissue as we see it: in 3D and stain free! Enjoy and stay tuned: the list of results grows every week…

The 3D Cell Explorer allows for:

  • Cancer cells detection based on morphological and RI markers 
  • Better 3D visualization of tumor in tissue slides

 

Histopathology of a patient’s biopsy has always been the most useful tool for detecting or confirming the presence of cancerous tissues. This is why patients usually have their cancer diagnosis confirmed on tissue pathology. Histopathologists interpret those diseased tissues under a microscope to make a diagnosis. However, the preparation of these samples can be tedious, expensive and time consuming. In order to view the tissue, the sections must be stained to create contrast. The 3D Cell Explorer offers a way to avoid this process. Based on the physical properties of the cells (the Refractive Index of the different components), a post acquisition digital staining of the sample can be performed, meaning no preparation pre-observation.

Slice of xenograft of human breast cancer in mouse . Cell line: MDA-mb-231 (part 1)

The mouse tumor was excised from the sacrificed animal, fixed in 4% PFA in PBS and embedded in OCT. The organ was then sectioned (8µm) in a cryostat and mounted on glass slides.

Slice of xenograft of human breast cancer in mouse. Cell line: MDA-mb-231 (part 2)

The mouse tumor was excised from the sacrificed animal, fixed in 4% PFA in PBS and embedded in OCT. The organ was then sectioned (8um) in a cryostat and mounted on glass slides.

Learn more about the 3D Cell Explorer

Read more about the 3D Cell Explorer here and learn how to use it in 1 minute with this video

Discover all the secrets of the 3D Cell Explorer on our Introductory webinar

Learn how to digitally stain your cells with our software STEVE, in 1 minute

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